Univ.-Prof. Dr. Verena Dirsch
Verena Dirsch

Coffey, C, Perhal, AF, Richter, W, Chen, Y, Linder, T, Schwaiger, S, Mihovilovic, MD, Kirchmair, J, Schnürch, M & Dirsch, VM 2026, 'Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans', European Journal of Medicinal Chemistry, vol. 302, no. Part 1, 118285. https://doi.org/10.1016/j.ejmech.2025.118285



Schwarz, PF, Perhal, AF, Guder, F, Hernández González, JE, Janssen, K, Sağıroğlu, E, Tahir, A, Kirchmair, J, Rochel, N, Dirsch, VM & Chen, Y 2025, 'Identification of New Lupane-Type Triterpenoids as Inverse Agonists of RAR-Related Orphan Receptor Gamma (RORγ)', Journal of Natural Products, vol. 88, no. 8, pp. 1887-1900. https://doi.org/10.1021/acs.jnatprod.5c00416

Treml, J, Václavík, J, Molčanová, L, Čulenová, M, Hummelbrunner, S, Neuhauser, C, Dirsch, VM, Weghuber, J & Šmejkal, K 2025, 'Identification of Plant Phenolics from Paulownia tomentosa and Morus alba as Novel PPARγ Partial Agonists and Hypoglycemic Agents', Journal of Agricultural and Food Chemistry, vol. 73, no. 22, pp. 13960-13972. https://doi.org/10.1021/acs.jafc.4c11398



Cannavacciuolo, C, Napolitano, A, Dirsch, VM, Heiss, EH, Masullo, M & Piacente, S 2025, 'Oleraceins from Portulaca oleracea leaves: Quali-quantitative determination and antioxidant potential', Current Research in Food Science, vol. 10, 100992. https://doi.org/10.1016/j.crfs.2025.100992

Perhal, AF, Papadopoulos, MGE, Medel-Lacruz, B, Ladurner, A, Selent, J, Dirsch, V & Kolb, P 2024, 'Discovery and characterization of small-molecule TGR5 ligands with agonistic activity', European Journal of Medicinal Chemistry, vol. 276, 116616. https://doi.org/10.1016/j.ejmech.2024.116616

Czollner, L, Papaplioura, E, Linder, T, Liu, R, Li, Y, Atanasov, AG, Dirsch, VM, Schnürch, M & Mihovilovic, MD 2023, 'A silver-coated copper wire as inexpensive drug eluting stent model: determination of the relative releasing properties of leoligin and derivatives', Monatshefte fur Chemie, vol. 154, no. 12, pp. 1317-1326. https://doi.org/10.1007/s00706-020-02677-4


Resetar, M, Tietcheu Galani, BR, Tsamo, AT, Chen, Y, Schachner, D, Stolzlechner, S, Mawouma Pagna, JI, Beniddir, MA, Kirchmair, J & Dirsch, VM 2023, 'Flindissone, a Limonoid Isolated from Trichilia prieuriana, Is an LXR Agonist', Journal of Natural Products, vol. 86, no. 8, pp. 1901-1909. https://doi.org/10.1021/acs.jnatprod.3c00059



Lapinskaite, R, Atalay, HN, Malatinec, Š, Donmez, S, Cinar, ZO, Schwarz, P, Perhal, AF, Císařová, I, Labanauskas, L, Karpiński, TM, Dirsch, V, Tumer, TB & Rycek, L 2023, 'Synthesis of Selagibenzophenone A and Its Derivatives for Evaluation of Their Antiproliferative, RORγ Inverse Agonistic, and Antimicrobial Effect', Chemistry SELECT, vol. 8, no. 7.

Blažević, T, Ciotu, CI, Gold-Binder, M, Heiss, EH, Fischer, MJM & Dirsch, VM 2023, 'Cultured rat aortic vascular smooth muscle cells do not express a functional TRPV1', PLoS ONE, vol. 18, no. 2, e0281191. https://doi.org/10.1371/journal.pone.0281191

Rollinger, JM, Langeder, J, Grienke, U, Kirchweger, B, Wasilewicz, A, Dirsch, V, Perhal, AF, Schwarz, P, Schmidtke, M, Doering, K, Schmietendorf, H, Rabenau, H, Cinatl, J & Bojkova, D, Sanggenon for antiviral treatment, Patent No. WO2023280767.



Nuclear receptors as targets for natural product (analogs).

Dirsch, V. (Speaker)

4 Nov 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


2D NMR-based biochemometric approach for natural product research: fishing bioactives out of multicomponent mixtures

Adelsberger, S. (Speaker), Perhal, A. F. (Contributor), Bertaina, L. (Contributor), Schwarz, P. (Contributor), Dirsch, V. (Contributor), Rollinger, J. M. (Contributor) & Grienke, U. (Contributor)

1 Sept 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


2D NMR-based biochemometrics for deciphering bioactive compounds in multicomponent herbal mixtures

Adelsberger, S. (Speaker), Perhal, A. F. (Contributor), Bertaina, L. (Contributor), Schwarz, P. (Contributor), Dirsch, V. (Contributor), Rollinger, J. M. (Contributor) & Grienke, U. (Contributor)

3 Jul 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nuclear receptors as targets for natural product (analogs).

Dirsch, V. (Invited speaker)

30 Jun 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nukleäre Rezeptoren als Targets für Naturstoffe in der Entzündungshemmung.

Dirsch, V. (Speaker)

10 Apr 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nuclear receptors as targets for natural product (analogs).

Dirsch, V. (Invited speaker)

7 Nov 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Nukleäre Rezeptoren als Targets für Naturstoffe und deren Analoga.

Dirsch, V. (Invited speaker)

15 May 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


RXR and ROR as targets for natural products and structural analogs.

Dirsch, V. (Speaker)

3 Nov 20235 Nov 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


RXR and ROR as targets for natural products and structural analogs.

Dirsch, V. (Speaker)

23 Oct 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


RXR and ROR as targets for natural product (analogs).

Dirsch, V. (Speaker)

4 Sept 20237 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


RXR and ROR as targets for natural products and structural analogs.

Dirsch, V. (Speaker)

1 Dec 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Impulse lecture: career options in academia.

Dirsch, V. (Speaker) & Rollinger, J. M. (Speaker)

19 May 202220 May 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Einfluss des Neolignans Honokiol auf die intestinale Barrierefunktion

Baumann, A. (Speaker), Habersatter, E. (Contributor), Schachner, D. (Contributor), Dirsch, V. (Contributor) & Bergheim, I. (Contributor)

17 Mar 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Neolignan analogs lead to a selective RXR modulator.

Dirsch, V. (Speaker)

24 Sept 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


From man to mice to molecules.

Dirsch, V. (Speaker)

5 Apr 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Discovery of new GPBAR1 agonists by combined in silico - in vitro screening

Kirchweger, B. (Speaker), Müller Kratz, J. (Contributor), Ladurner, A. (Contributor), Grienke, U. (Contributor), Dirsch, V. (Contributor), Langer, T. (Contributor) & Rollinger, J. M. (Contributor)

26 Aug 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Neolignan derivatives as RXR selective modulators – A promising approach against metabolic disease?

Dirsch, V. (Speaker)

12 Jun 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Neolignan-derived rexinoids: promising modulators in metabolic disease?

Dirsch, V. (Speaker)

2 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Neolignan-derived rexinoids: promising modulators in metabolic disease?

Dirsch, V. (Speaker)

19 Apr 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Das Berufsbild des Hochschullehrers im Wandel, Symposium: Hochschullehrer 2030 – endangered species or global player.

Dirsch, V. (Speaker)

20 Oct 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Pharmacognosy and Pharmacology: two sides of one coin?

Dirsch, V. (Speaker)

30 Sept 2016

Activity: Talks and presentationsTalk or oral contributionOther


From man to mice to molecules.

Dirsch, V. (Speaker)

16 May 2016

Activity: Talks and presentationsTalk or oral contributionOther


RXRα and neolignans – a promising approach against metabolic disease?

Dirsch, V. (Speaker)

11 Apr 2016

Activity: Talks and presentationsTalk or oral contributionOther


Bioactives from Natural Sources – a Vienna perspective.

Dirsch, V. (Speaker)

7 Oct 2015

Activity: Talks and presentationsTalk or oral contributionOther


Bioactives from Natural Sources – new opportunities using approaches from molecular biology.

Dirsch, V. (Speaker)

16 Oct 2014

Activity: Talks and presentationsTalk or oral contributionOther


Neolignans: from PPARγ to RXRα

Dirsch, V. (Speaker)

25 Sept 2014

Activity: Talks and presentationsTalk or oral contributionOther


Biosimilars.

Dirsch, V. (Speaker)

24 May 2014

Activity: Talks and presentationsTalk or oral contributionOther


Natural products in vascular biology - molecular mechanisms.

Dirsch, V. (Invited speaker)

22 Nov 2012

Activity: Talks and presentationsTalk or oral contributionOther


Natural products as leads and tools in cardiovascular research.

Dirsch, V. (Invited speaker)

4 Oct 2012

Activity: Talks and presentationsTalk or oral contributionOther


Leads and Lessons from Natural Products.

Dirsch, V. (Invited speaker)

12 Dec 2011

Activity: Talks and presentationsTalk or oral contributionOther


Naturstoffe in der Gefäßbiologie – Molekulare Wirkmechanismen.

Dirsch, V. (Invited speaker)

1 Dec 2011

Activity: Talks and presentationsTalk or oral contributionOther


Bioactive natural products targeting inflammation.

Dirsch, V. (Invited speaker)

23 Sept 2011

Activity: Talks and presentationsTalk or oral contributionOther


Natural products as leads and tools in cardiovascular research.

Dirsch, V. (Invited speaker)

16 Jun 2011

Activity: Talks and presentationsTalk or oral contributionOther


Natural products and redox regulation.

Dirsch, V. (Invited speaker)

15 Jul 2010

Activity: Talks and presentationsTalk or oral contributionOther


Effect of roscovitine and derivatives in PDGF-activated VSMC.

Dirsch, V. (Invited speaker)

14 Jun 2010

Activity: Talks and presentationsTalk or oral contributionOther


Natural products as leads and tools in cardiovascular research

Dirsch, V. (Invited speaker)

20 Nov 2009

Activity: Talks and presentationsTalk or oral contributionOther


Leads and Lessons from Nature

Dirsch, V. (Invited speaker)

17 Oct 2009

Activity: Talks and presentationsTalk or oral contributionOther


Naturstoffe in der Gefäßbiologie – molekulare Wirkmechanismen

Dirsch, V. (Speaker)

21 Jul 2009

Activity: Talks and presentationsTalk or oral contributionOther


Virtual and real screening of natural products to find effective modulators of protein tyrosine phosphatase PTP1B.

Dirsch, V. (Contributor)

18 Apr 2009

Activity: Talks and presentationsTalk or oral contributionOther


Natural products – leads and lessons

Dirsch, V. (Speaker)

3 Mar 2009

Activity: Talks and presentationsTalk or oral contributionOther


Vasoprotection by inhibition of vascular smooth muscle cell growth and migration.

Dirsch, V. (Invited speaker)

18 Jul 2008

Activity: Talks and presentationsTalk or oral contributionOther


Natural product-driven chemical biology: a useful concept for target identification?

Dirsch, V. (Invited speaker)

11 Jul 2008

Activity: Talks and presentationsTalk or oral contributionOther


Leads and lessions from natural products.

Dirsch, V. (Invited speaker)

5 May 2008

Activity: Talks and presentationsTalk or oral contributionOther


Austrian red wines and their effects on endothelial nitric oxide synthase

Dirsch, V. (Contributor)

25 Apr 2008

Activity: Talks and presentationsTalk or oral contributionOther


Antioxidantien, pflanzliche Polyphenole: was können Rotwein und Co?

Dirsch, V. (Invited speaker)

26 Oct 2007

Activity: Talks and presentationsTalk or oral contributionOther


Gefäßschutz durch Zellwachstumshemmung - vom Naturstoff zum Target

Dirsch, V. (Invited speaker)

10 Oct 2007

Activity: Talks and presentationsTalk or oral contributionOther


Natural products and chronic inflamnmatory vascular processes.

Dirsch, V. (Invited speaker)

2 Sept 2007

Activity: Talks and presentationsTalk or oral contributionOther


Selective inhibition of platelet-derived growth factor-induced signalling cascades by indirubin-3'-monoxime

Dirsch, V. (Contributor)

2 Sept 2007

Activity: Talks and presentationsTalk or oral contributionOther


Chronic resveratrol induces a redox- dependent senescent-like growth arrest - role of the S-phase arrest

Dirsch, V. (Contributor)

13 Mar 2007

Activity: Talks and presentationsTalk or oral contributionOther


Effects of indirubin-3`-monoxime on platelet-derived growth factor signaling

Dirsch, V. (Contributor)

6 Sept 2006

Activity: Talks and presentationsTalk or oral contributionOther


Natural products: small molecule tools to probe for pharmacological targets?

Dirsch, V. (Contributor)

18 Nov 2005

Activity: Talks and presentationsTalk or oral contributionOther


Rotwein - die angenehme Art dem Herzinfarkt vorzubeugen ?

Dirsch, V. (Speaker)

18 Oct 2005

Activity: Talks and presentationsTalk or oral contributionOther


Naturstoffe - nicht nur ideal zur Wirkstoff- sondern auch zur Targetsuche?

Dirsch, V. (Contributor)

20 Jun 2005

Activity: Talks and presentationsTalk or oral contributionOther


Mit einem Naturstoff auf Target-Suche: Shp2, ein Hemmer vaskulärer Hypertrophie?

Dirsch, V. (Contributor)

28 Jan 2005

Activity: Talks and presentationsTalk or oral contributionOther


Rotweinpolyphenole - die angenehme Art dem Herzinfarkt vorzubeugen?

Dirsch, V. (Contributor)

26 Oct 2004

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol hemmt die Angiotensin II-induzierte Hypertrophie in vaskulären glatten Muskelzellen - aber über welches Target?

Dirsch, V. (Contributor)

28 Jun 2004

Activity: Talks and presentationsTalk or oral contributionOther


Polyphenole aus dem Rotwein - eine Erklärung für das "French Paradox"?

Dirsch, V. (Contributor)

25 May 2004

Activity: Talks and presentationsTalk or oral contributionOther


Mittels Resveratrol von der Angiotensin II-induzierten Hypertrophie zur Phosphatase Shp2

Dirsch, V. (Contributor)

24 May 2004

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol: Einfluss auf Proliferation/Zellzyklus und die Angiotensin II-induzierte Hypertrophy von vaskulären glatten Muskelzellen.

Dirsch, V. (Contributor)

21 Apr 2004

Activity: Talks and presentationsTalk or oral contributionOther


NO French Paradox without red wine polyphenols?

Dirsch, V. (Contributor)

31 Mar 2004

Activity: Talks and presentationsTalk or oral contributionOther


Naturstoffe als Tools?: was uns Resveratrol über das Angiotensin II Signaling in vaskulären glatten Muskelzellen erzählt......

Dirsch, V. (Contributor)

28 Jan 2004

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol and other cardiovascular active natural products.

Dirsch, V. (Contributor)

19 Jun 2003

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol: Einfluss auf Proliferation und Zellzyklus von vaskulären glatten Muskelzellen

Dirsch, V. (Contributor)

4 Jun 2003

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol: Mechanismen der Wachstumshemmung von vaskulären glatten Muskelzellen

Dirsch, V. (Contributor)

28 Apr 2003

Activity: Talks and presentationsTalk or oral contributionOther


Mechanism of vascular smooth muscle cell growth arrest by resveratrol

Dirsch, V. (Contributor)

22 Apr 2003

Activity: Talks and presentationsTalk or oral contributionOther


Einfluss von Resveratrol auf Zellzyklus und Proliferation von vaskulären glatten Muskelzellen

Dirsch, V. (Contributor)

9 Apr 2003

Activity: Talks and presentationsTalk or oral contributionOther


Resveratrol: Mechanismen der Wachstumshemmung von glatten Muskelzellen

Dirsch, V. (Contributor)

16 Dec 2002

Activity: Talks and presentationsTalk or oral contributionOther


Vasoprotective compounds made by nature?

Dirsch, V. (Contributor)

27 Jun 2002

Activity: Talks and presentationsTalk or oral contributionOther



Resveratrol, eine vielversprechende Substanz zur Prävention von Atherosklerose?

Dirsch, V. (Contributor)

10 Dec 2001

Activity: Talks and presentationsTalk or oral contributionOther


Cell-based techniques for the discovery and characterisation of anti-inflammatory natural products

Dirsch, V. (Invited speaker)

8 Oct 2001

Activity: Talks and presentationsTalk or oral contributionOther


Das Triterpen-Chinonmethid Pristimerin hemmt die Induktion der induzierbaren NO-Synthase in LPS-aktivierten RAW 264.7 Makrophagen

Dirsch, V. (Invited speaker)

2 Dec 1998

Activity: Talks and presentationsTalk or oral contributionOther


Der Einfluß von Allicin und Ajoen. zwei Verbindungen aus dem Knoblauch, auf die induzierbare NO-Synthase

Dirsch, V. (Speaker)

8 May 1998

Activity: Talks and presentationsTalk or oral contributionOther


Department of Pharmaceutical Sciences

Deputy Head

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2G452

T: +43-1-4277-55270

verena.dirsch@univie.ac.at