Dipl.-Ing. (FH) Dr. Daniela Digles
T: +43-1-4277-55007
Winter term 2025
321024 PR Arzneistoffanalytik - B12 - (5 Kurse)
Summer term 2025
321024 PR Arzneistoffanalytik - B12 - (5 Kurse)
Goldmann, U, Wiedmer, T, Garofoli, A, Sedlyarov, V, Bichler, M, Haladik, B, Wolf, G, Christodoulaki, E, Ingles-Prieto, A, Ferrada, E, Frommelt, F, Teoh, ST, Leippe, P, Onea, G, Pfeifer, M, Kohlbrenner, M, Chang, L, Selzer, P, Reinhardt, J, Digles, D, Ecker, GF, Osthushenrich, T, MacNamara, A, Malarstig, A, Hepworth, D & Superti-Furga, G 2025, 'Data- and knowledge-derived functional landscape of human solute carriers', Molecular Systems Biology, vol. 21, no. 6, 33, pp. 599-631. https://doi.org/10.1038/s44320-025-00108-2

Digles, D, Ingles-Prieto, A, Dvorak, V, Mocking, TAM, Goldmann, U, Garofoli, A, Homan, EJ, Di Silvio, A, Azzollini, L, Sassone, F, Fogazza, M, Bärenz, F, Pommereau, A, Zuschlag, Y, Ooms, JF, Tranberg-Jensen, J, Hansen, JS, Stanka, J, Sijben, HJ, Batoulis, H, Bender, E, Martini, R, IJzerman, AP, Sauer, DB, Heitman, LH, Manolova, V, Reinhardt, J, Ehrmann, A, Leippe, P, Ecker, GF, Huber, KVM, Licher, T, Scarabottolo, L, Wiedmer, T & Superti-Furga, G 2024, 'Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily', Frontiers in Pharmacology, vol. 15, 1401599. https://doi.org/10.3389/fphar.2024.1401599


Huang, J, Osthushenrich, T, MacNamara, A, Mälarstig, A, Brocchetti, S, Bradberry, S, Scarabottolo, L, Ferrada, E, Sosnin, S, Digles, D, Superti-Furga, G & Ecker, GF 2024, 'ProteoMutaMetrics: Machine Learning Approaches for Solute Carrier Family 6 Mutation Pathogenicity Prediction', Rsc advances, vol. 14, no. 19, 00748, pp. 13083-13094. https://doi.org/10.1039/d4ra00748d

Agrawal, A, Balcı, H, Hanspers, K, Coort, SL, Martens, M, Slenter, DN, Ehrhart, F, Digles, D, Waagmeester, A, Wassink, I, Abbassi-Daloii, T, Lopes, EN, Iyer, A, Acosta, JM, Willighagen, LG, Nishida, K, Riutta, A, Basaric, H, Evelo, CT, Willighagen, EL, Kutmon, M & Pico, AR 2024, 'WikiPathways 2024: next generation pathway database', Nucleic Acids Research, vol. 52, no. D1, pp. D679-D689. https://doi.org/10.1093/nar/gkad960

Hanspers, K, Kutmon, M, Coort, SL, Digles, D, Dupuis, LJ, Ehrhart, F, Hu, F, Lopes, EN, Martens, M, Pham, N, Shin, W, Slenter, DN, Waagmeester, A, Willighagen, EL, Winckers, LA, Evelo, CT & Pico, AR 2021, 'Ten simple rules for creating reusable pathway models for computational analysis and visualization', PLoS Computational Biology, vol. 17, no. 8, e1009226. https://doi.org/10.1371/journal.pcbi.1009226

Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, LH, IJzerman, AP, Kell, DB, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, HJ, Steck, A-L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, CM & Superti-Furga, G 2021, 'An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters', Frontiers in Pharmacology, vol. 12, 722889. https://doi.org/10.3389/fphar.2021.722889

Martens, M, Ammar, A, Riutta, A, Waagmeester, A, Slenter, DN, Hanspers, K, Miller, R, Digles, D, Lopes, E, Ehrhart, F, Dupuis, L, Winckers, L, Coort, SL, Willighagen, EL, Evelo, CT, Pico, AR & Kutmon, M 2021, 'WikiPathways: Connecting Communities', Nucleic Acids Research, vol. 49, no. D1, pp. D613–D621. https://doi.org/10.1093/nar/gkaa1024

Superti-Furga, G, Lackner, D, Wiedmer, T, Ingles-Prieto, A, RESOLUTE consortium & Steppan, C 2020, 'The RESOLUTE consortium: unlocking SLC transporters for drug discovery', Nature Reviews. Drug Discovery, vol. 19, no. 7, pp. 429-430. https://doi.org/10.1038/d41573-020-00056-6

Hemmerich, J, Gurinova, J & Digles, D 2020, 'Accessing public compound databases with KNIME', Current Medicinal Chemistry, vol. 27, no. 38, pp. 6444-6457. https://doi.org/10.2174/0929867326666190801152317

Miller, RA, Woollard, P, Willighagen, EL, Digles, D, Kutmon, M, Loizou, A, Waagmeester, A, Senger, S & Evelo, CT 2018, 'Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform', F1000Research, vol. 7, 75. https://doi.org/10.12688/F1000RESEARCH.13197.2


Digles, D, Caracoti, A & Jacoby, E 2018, Accessing the Open PHACTS Discovery Platform with Workflow Tools. in B Wagner (ed.), Phenotypic Screening: Methods and Protocols. Springer, New York, Methods in Molecular Biology, vol. 1787, pp. 183-193. https://doi.org/10.1007/978-1-4939-7847-2_14

Kotsampasakou, E, Jain, S, Digles, D & Ecker, GF 2018, Transporters in Hepatotoxicity. in Computational Toxicology: Risk Assessment for Chemicals. Wiley, pp. 145-174. https://doi.org/10.1002/9781119282594.ch6

Slenter, DN, Kutmon, M, Hanspers, K, Riutta, A, Windsor, J, Nunes, N, Mélius, J, Cirillo, E, Coort, SL, Digles, D, Ehrhart, F, Giesbertz, P, Kalafati, M, Martens, M, Miller, R, Nishida, K, Rieswijk, L, Waagmeester, A, Eijssen, LMT, Evelo, CT, Pico, AR & Willighagen, EL 2018, 'WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research', Nucleic Acids Research, vol. 46, no. D1, pp. D661–D667. https://doi.org/10.1093/nar/gkx1064

Goldmann, D, Zdrazil, B, Digles, D & Ecker, GF 2017, 'Empowering pharmacoinformatics by linked life science data', Journal of Computer-Aided Molecular Design, vol. 31, no. 3, pp. 319-328. https://doi.org/10.1007/s10822-016-9990-4

Viereck, M, Gaulton, A & Digles, D 2017, Insights into Transporter Classifications: an Outline of Transporters as Drug Targets. in Transporters as Drug Targets. Wiley-VCH Verlag, pp. 1-20. https://doi.org/10.1002/9783527679430.ch1


Digles, D, Zdrazil, B, Neefs, JM, Van Vlijmen, H, Herhaus, C, Caracoti, A, Brea, J, Roibás, B, Loza, MI, Queralt-Rosinach, N, Furlong, LI, Gaulton, A, Bartek, L, Senger, S, Chichester, C, Engkvist, O, Evelo, CT, Franklin, NI, Marren, D, Ecker, GF & Jacoby, E 2016, 'Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: Knowing the knowns', MedChemComm, vol. 7, no. 6, pp. 1237-1244. https://doi.org/10.1039/c6md00065g

Chichester, C, Digles, D, Siebes, R, Loizou, A, Groth, P & Harland, L 2015, 'Drug discovery FAQs: Workflows for answering multidomain drug discovery questions', Drug Discovery Today, vol. 20, no. 4, pp. 399-405. https://doi.org/10.1016/j.drudis.2014.11.006

The quest for the key to the transporter fortress – collecting tool compounds for SLCs

Digles, D. (Speaker)

29 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


KNIME workshop - Similarity search for molecules with KNIME

Digles, D. (Speaker)

14 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Connecting Solute Carrier (SLC) resources with KNIME

Digles, D. (Speaker)

13 Sept 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Accessing public databases with KNIME

Digles, D. (Speaker)

17 Sept 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


ReSOLUTE databases and tools for the scientific community

Digles, D. (Speaker)

20 Sept 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


KNIME + Open PHACTS & Hands-on

Digles, D. (Speaker)

20 Oct 2016

Activity: Talks and presentationsTalk or oral contributionOther


Drug Targets in the Solute Carrier Classification (SLC)

Digles, D. (Speaker)

31 Aug 2016

Activity: Talks and presentationsTalk or oral contributionOther


Exploring available compound data with the open PHACTS discovery platform and KNIME

Digles, D. (Speaker)

21 Aug 2016

Activity: Talks and presentationsTalk or oral contributionOther


Academic use case: ErbB signaling

Digles, D. (Speaker)

26 Jun 2014

Activity: Talks and presentationsTalk or oral contributionOther


Using the Open PHACTS API with KNIME

Digles, D. (Speaker)

26 Jun 2014

Activity: Talks and presentationsTalk or oral contributionOther


Knowledge management for transmembrane transporters

Digles, D. (Speaker)

30 Oct 2013

Activity: Talks and presentationsTalk or oral contributionOther


In silico screening for insulin mimetic compounds using self-organizing maps

Digles, D. (Speaker)

19 Apr 2012

Activity: Talks and presentationsTalk or oral contributionOther


Department of Pharmaceutical Sciences

Josef-Holaubek-Platz 2 (UZA II)
1090 Wien
Room: 2E407

T: +43-1-4277-55007

daniela.digles@univie.ac.at